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浅析重性抑郁症患者生存质量及其与氟西汀治疗的关系
以显著提高重性抑郁症患者的生存质量，但并不能使其生存质量恢复到正常人群水平，这可能与药物临床疗效、药物不良反应、药物的其他作用机制或患者认知功能有关，尚需进一步探讨研究。
【参考文献】
1 孙延强,程凤莲,赵相英.传统与新型抗抑郁药对抑郁症病人疗效及生活质量影响的双盲对照研究.中国行为医学科学,2004,13（5）：530-531.
2 Gregory E,Michael SCD,John H.Initial antidepressant choice in primary care:effectiveness and cost of fluoxetine vs tricyclic antidepressants.Journal of the American Medical Association,1996,275（24）:1897-1902.
3 Tollefson GD,Holman SL,Syler ME,et al.Fluoxetine,placebo,tricyclic antidepressants in major depression with,without anxious features.J Clin Psychiatry,1994,55:50-59.
4 Stokes P.Fluoxetine:a five-year review.Clin Ther,1993,15:216-243.
5 Hamilton M.Development of psychiatric rating scale for primary depression.Brit Soc Clin Psychol,1967,6:278-296.
6 Souetre E,Martin P,Lozet H，et al.Quality of life in depressed patients:comparison of fluoxetine and major tricyclic antidepressants.Int Clin Psychopharmacol,1996,11（1）:45-52.
7 施慎逊，张明圆，王祖新,等.氟西汀治疗抑郁症的多中心开放性对照研究.中华精神科杂志,1997,30（1）:74.
8 Ware JE Jr,Snow KK,Kosinski M,et al.SF-36 health survey:manual and interpretation guide.Boston,Mass:The Health Institute,New England Medical Center,1993.
9 方积乾.行为医学量表手册.健康状况问卷.中国行为医学科学，2001,10:19-24.
10 Gandek B,Ware JE.Methods for validating and norming translations of health status questionnaires:the IQOLA Project approach.Inter-national quality of life assesment.J Clin Epidemiol,1998,51（11）:953-959.
11 关念红,张晋碚,韩自力,等.舍曲林、氟西汀和帕罗西汀对抑郁症患者生活质量和经济负担的影响.中国行为医学科学,2002,11（6）:637-638.
［Abstract］ Objective To investigate the life quality of major depression patients and the influence of fluoxetine on life quality in major depression.Methods We used the method of case-control study. HAMD,SF-36 and TESS were used to evaluate the depressed symptoms,life qualities and side reaction.All patients were given six-week therapies of fluoxetine and assessed with above scales before and after therapy.T test and ANOVA were used to compare means between groups.The Pearson correlation analysis was done between clinical effect of fluoxetine and improvement of life quality.Results （1）Life qualities of patients （before and after treatment） were significantly lower than normal group.（2）Six-week treatment later,each factor’s score of SF-36 had a significant difference compared with the score before therapy （P<0.01～0.05）.（3）There was a certain direct correlation between HAMD reductive ratio and life quality （P＜0.01～0.05）.In addition,side reactions were also influence the life quality.The scores of PF and VT in side reactions group were lower than those of group without side reactions. Conclusion Life quality of major depression decreases significantly. Fluoxetine can improve the life quality of patients notably in six weeks,but can not make the life quality get the normal level in short term.There is a certain positive correlation between the effect of fluoxetine and improvement of life quality in patients. Meanwhile life quality is also influenced by other factors such as side reactions of drug and so on.
［Key words］ major depression;quality of life;fluoxetine;influential factor
【参考文献】
1 孙延强,程凤莲,赵相英.传统与新型抗抑郁药对抑郁症病人疗效及生活质量影响的双盲对照研究.中国行为医学科学,2004,13（5）：530-531.
2 Gregory E,Michael SCD,John H.Initial antidepressant choice in primary care:effectiveness and cost of fluoxetine vs tricyclic antidepressants.Journal of the American Medical Association,1996,275（24）:1897-1902.
3 Tollefson GD,Holman SL,Syler ME,et al.Fluoxetine,placebo,tricyclic antidepressants in major depression with,without anxious features.J Clin Psychiatry,1994,55:50-59.
4 Stokes P.Fluoxetine:a five-year review.Clin Ther,1993,15:216-243.
5 Hamilton M.Development of psychiatric rating scale for primary depression.Brit Soc Clin Psychol,1967,6:278-296.
6 Souetre E,Martin P,Lozet H，et al.Quality of life in depressed patients:comparison of fluoxetine and major tricyclic antidepressants.Int Clin Psychopharmacol,1996,11（1）:45-52.
7 施慎逊，张明圆，王祖新,等.氟西汀治疗抑郁症的多中心开放性对照研究.中华精神科杂志,1997,30（1）:74.
8 Ware JE Jr,Snow KK,Kosinski M,et al.SF-36 health survey:manual and interpretation guide.Boston,Mass:The Health Institute,New England Medical Center,1993.
9 方积乾.行为医学量表手册.健康状况问卷.中国行为医学科学，2001,10:19-24.
10 Gandek B,Ware JE.Methods for validating and norming translations of health status questionnaires:the IQOLA Project approach.Inter-national quality of life assesment.J Clin Epidemiol,1998,51（11）:953-959.
11 关念红,张晋碚,韩自力,等.舍曲林、氟西汀和帕罗西汀对抑郁症患者生活质量和经济负担的影响.中国行为医学科学,2002,11（6）:637-638.
［Abstract］ Objective To investigate the life quality of major depression patients and the influence of fluoxetine on life quality in major depression.Methods We used the method of case-control study. HAMD,SF-36 and TESS were used to evaluate the depressed symptoms,life qualities and side reaction.All patients were given six-week therapies of fluoxetine and assessed with above scales before and after therapy.T test and ANOVA were used to compare means between groups.The Pearson correlation analysis was done between clinical effect of fluoxetine and improvement of life quality.Results （1）Life qualities of patients （before and after treatment） were significantly lower than normal group.（2）Six-week treatment later,each factor’s score of SF-36 had a significant difference compared with the score before therapy （P<0.01～0.05）.（3）There was a certain direct correlation between HAMD reductive ratio and life quality （P＜0.01～0.05）.In addition,side reactions were also influence the life quality.The scores of PF and VT in side reactions group were lower than those of group without side reactions. Conclusion Life quality of major depression decreases significantly. Fluoxetine can improve the life quality of patients notably in six weeks,but can not make the life quality get the normal level in short term.There is a certain positive correlation between the effect of fluoxetine and improvement of life quality in patients. Meanwhile life quality is also influenced by other factors such as side reactions of drug and so on.
［Key words］ major depression;quality of life;fluoxetine;influential factor
